Publications Archive

2024

Nat Commun. 2024 Nov 14;15(1):9871. doi: 10.1038/s41467-024-54232-y.

Dichotomous outcomes of TNFR1 and TNFR2 signaling in NK cell-mediated immune responses during inflammation

Timothy R McCulloch, Gustavo R Rossi, Louisa Alim, Pui Yeng Lam, Joshua K M Wong, Elaina Coleborn, Snehlata Kumari, Colm Keane, Andrew J Kueh, Marco J Herold, Christoph Wilhelm, Percy A Knolle, Lawrence Kane, Timothy J Wells, Fernando Souza-Fonseca-Guimaraes

Service type: Stock strains

2024

Brain Behav Immun. 2024 Nov 13:124:1-8. doi: 10.1016/j.bbi.2024.11.018. Online ahead of print.

Prolonged STAT1 signaling in neurons causes hyperactive behavior

Danielle N Clark, Shelby V Brown, Li Xu, Rae-Ling Lee, Joey V Ragusa, Zhenghao Xu, Joshua D Milner, Anthony J Filiano

Service type: Knock-in mice

2024

Eur J Immunol. 2024 Nov 9:e202350890. doi: 10.1002/eji.202350890.

B Cells With Complementary B Cell Receptors Can Kill Each Other

Ramakrishna Prabhu Gopalakrishnan, Marius Sigurdsson Østrøm, Frode Miltzow Skjeldal, Oddmund Bakke, Bjarne Bogen, Peter Csaba Huszthy

Service type: Knock-in mice

2024

BMC Cancer. 2024 Nov 4;24(1):1350. doi: 10.1186/s12885-024-13088-7.

Osteosarcoma cells depend on MCL-1 for survival, and osteosarcoma metastases respond to MCL-1 antagonism plus regorafenib in vivo

Yanhao Ji, Michael A Harris, Lucas M Newton, Tiffany J Harris, W Douglas Fairlie, Erinna F Lee, Christine J Hawkins

Service type: Stock strains

2024

Adv Healthc Mater. 2024 Oct 23:e2401939. doi: 10.1002/adhm.202401939.

Humanized In Vivo Bone Tissue Engineering: In Vitro Preculture Conditions Control the Structural, Cellular, and Matrix Composition of Humanized Bone Organs

Agathe Bessot, Flavia Medeiros Savi, Jennifer Gunter, Jayanti Mendhi, Shahrouz Amini, David Waugh, Jacqui McGovern, Dietmar W Hutmacher, Nathalie Bock

Service type: Stock strains

2024

Sci Adv. 2024 Oct 4;10(40):eadn8760. doi: 10.1126/sciadv.adn8760. Epub 2024 Oct 4.

The generation of stable microvessels in ischemia is mediated by endothelial cell derived TRAIL

Siân P Cartland, Manisha S Patil, Elaina Kelland, Natalie Le, Lauren Boccanfuso, Christopher P Stanley, Pradeep Manuneedhi Cholan, Malathi I Dona, Ralph Patrick, Jordan McGrath, Qian Peter Su, Imala Alwis, Ruth Ganss, Joseph E Powell, Richard P Harvey, Alexander R Pinto, Thomas S Griffith, Jacky Loa, Sarah J Aitken, David A Robinson, Sanjay Patel, Mary M Kavurma

Service type: Knockout mice

2024

Eur J Pharm Biopharm. 2024 Oct:203:114453. doi: 10.1016/j.ejpb.2024.114453. Epub 2024 Aug 10.

Contrasting the pharmacokinetic performance and gut microbiota effects of an amorphous solid dispersion and lipid nanoemulsion for a poorly water-soluble anti-psychotic

Tahlia R Meola, Srinivas Kamath, Aurelia S Elz, Clive A Prestidge, Anthony Wignall, Paul Joyce

Service type: Stock strains

2024

Oncoimmunology. 2024 Sep 22;13(1):2406576. doi: 10.1080/2162402X.2024.2406576. eCollection 2024.

Immune priming and induction of tertiary lymphoid structures in a cord-blood humanized mouse model of gastrointestinal stromal tumor

Bo He, Larissa Dymond, Kira H Wood, Edward R Bastow, Jiulia Satiaputra, Ji Li, Anna Johansson-Percival, Juliana Hamzah, M Priyanthi Kumarasinghe, Mohammed Ballal, Jonathan Foo, Mikael Johansson, Hooi C Ee, Scott W White, Louise Winteringham, Ruth Ganss

Service type: Stock strains

2024

Elife. 2024 Sep 17:12:RP92173. doi: 10.7554/eLife.92173.

DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

Ernie Yulyaningsih, Jung H Suh, Melania Fanok, Roni Chau, Hilda Solanoy, Ryan Takahashi, Anna I Bakardjiev, Isabel Becerra, N Butch Benitez, Chi-Lu Chiu, Sonnet S Davis, William E Dowdle, Timothy Earr, Anthony A Estrada, Audrey Gill, Connie Ha, Patrick C G Haddick, Kirk R Henne, Martin Larhammar, Amy W-S Leung, Romeo Maciuca, Bahram Memarzadeh, Hoang N Nguyen, Alicia A Nugent, Maksim Osipov, Yingqing Ran, Kevin Rebadulla, Elysia Roche, Thomas Sandmann, Jing Wang, Joseph W Lewcock, Kimberly Scearce-Levie, Lesley A Kane, Pascal E Sanchez

Service type: Knock-in mice

2024

Nat Commun. 2024 Sep 12;15(1):7998. doi: 10.1038/s41467-024-52396-1.

Clearance and transport of amyloid β by peripheral monocytes correlate with Alzheimer’s disease progression

Xin Huang, Chris Fowler, Yihan Li, Qiao-Xin Li, Jiaqi Sun, Yijun Pan, Liang Jin, Keyla A Perez, Céline Dubois, Yen Y Lim, Candace Drysdale, Rebecca L Rumble, Holly R Chinnery, Christopher C Rowe, Ralph N Martins, Paul Maruff, James D Doecke, Yong Lin, Abdel A Belaidi, Kevin J Barnham, Colin L Masters, Ben J Gu

Service type: Stock strains

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Dichotomous outcomes of TNFR1 and TNFR2 signaling in NK cell-mediated immune responses during inflammation

Prolonged STAT1 signaling in neurons causes hyperactive behavior

B Cells With Complementary B Cell Receptors Can Kill Each Other

Osteosarcoma cells depend on MCL-1 for survival, and osteosarcoma metastases respond to MCL-1 antagonism plus regorafenib in vivo

Humanized In Vivo Bone Tissue Engineering: In Vitro Preculture Conditions Control the Structural, Cellular, and Matrix Composition of Humanized Bone Organs

The generation of stable microvessels in ischemia is mediated by endothelial cell derived TRAIL

Contrasting the pharmacokinetic performance and gut microbiota effects of an amorphous solid dispersion and lipid nanoemulsion for a poorly water-soluble anti-psychotic

Immune priming and induction of tertiary lymphoid structures in a cord-blood humanized mouse model of gastrointestinal stromal tumor

DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

Clearance and transport of amyloid β by peripheral monocytes correlate with Alzheimer’s disease progression

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