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2024

Sci Adv. 2024 Oct 4;10(40):eadn8760. doi: 10.1126/sciadv.adn8760. Epub 2024 Oct 4.

The generation of stable microvessels in ischemia is mediated by endothelial cell derived TRAIL

Siân P Cartland, Manisha S Patil, Elaina Kelland, Natalie Le, Lauren Boccanfuso, Christopher P Stanley, Pradeep Manuneedhi Cholan, Malathi I Dona, Ralph Patrick, Jordan McGrath, Qian Peter Su, Imala Alwis, Ruth Ganss, Joseph E Powell, Richard P Harvey, Alexander R Pinto, Thomas S Griffith, Jacky Loa, Sarah J Aitken, David A Robinson, Sanjay Patel, Mary M Kavurma

Service type: Knockout mice

2024

Eur J Pharm Biopharm. 2024 Oct:203:114453. doi: 10.1016/j.ejpb.2024.114453. Epub 2024 Aug 10.

Contrasting the pharmacokinetic performance and gut microbiota effects of an amorphous solid dispersion and lipid nanoemulsion for a poorly water-soluble anti-psychotic

Tahlia R Meola, Srinivas Kamath, Aurelia S Elz, Clive A Prestidge, Anthony Wignall, Paul Joyce

Service type: Stock strains

2024

Oncoimmunology. 2024 Sep 22;13(1):2406576. doi: 10.1080/2162402X.2024.2406576. eCollection 2024.

Immune priming and induction of tertiary lymphoid structures in a cord-blood humanized mouse model of gastrointestinal stromal tumor

Bo He, Larissa Dymond, Kira H Wood, Edward R Bastow, Jiulia Satiaputra, Ji Li, Anna Johansson-Percival, Juliana Hamzah, M Priyanthi Kumarasinghe, Mohammed Ballal, Jonathan Foo, Mikael Johansson, Hooi C Ee, Scott W White, Louise Winteringham, Ruth Ganss

Service type: Stock strains

2024

Elife. 2024 Sep 17:12:RP92173. doi: 10.7554/eLife.92173.

DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

Ernie Yulyaningsih, Jung H Suh, Melania Fanok, Roni Chau, Hilda Solanoy, Ryan Takahashi, Anna I Bakardjiev, Isabel Becerra, N Butch Benitez, Chi-Lu Chiu, Sonnet S Davis, William E Dowdle, Timothy Earr, Anthony A Estrada, Audrey Gill, Connie Ha, Patrick C G Haddick, Kirk R Henne, Martin Larhammar, Amy W-S Leung, Romeo Maciuca, Bahram Memarzadeh, Hoang N Nguyen, Alicia A Nugent, Maksim Osipov, Yingqing Ran, Kevin Rebadulla, Elysia Roche, Thomas Sandmann, Jing Wang, Joseph W Lewcock, Kimberly Scearce-Levie, Lesley A Kane, Pascal E Sanchez

Service type: Knock-in mice

2024

Nat Commun. 2024 Sep 12;15(1):7998. doi: 10.1038/s41467-024-52396-1.

Clearance and transport of amyloid β by peripheral monocytes correlate with Alzheimer’s disease progression

Xin Huang, Chris Fowler, Yihan Li, Qiao-Xin Li, Jiaqi Sun, Yijun Pan, Liang Jin, Keyla A Perez, Céline Dubois, Yen Y Lim, Candace Drysdale, Rebecca L Rumble, Holly R Chinnery, Christopher C Rowe, Ralph N Martins, Paul Maruff, James D Doecke, Yong Lin, Abdel A Belaidi, Kevin J Barnham, Colin L Masters, Ben J Gu

Service type: Stock strains

2024

Cell. 2024 Sep 12:S0092-8674(24)00965-6. doi: 10.1016/j.cell.2024.08.036. Online ahead of print.

Dynamic allostery drives autocrine and paracrine TGF-β signaling

Mingliang Jin, Robert I Seed, Guoqing Cai, Tiffany Shing, Li Wang, Saburo Ito, Anthony Cormier, Stephanie A Wankowicz, Jillian M Jespersen, Jody L Baron, Nicholas D Carey, Melody G Campbell, Zanlin Yu, Phu K Tang, Pilar Cossio, Weihua Wen, Jianlong Lou, James Marks, Stephen L Nishimura, Yifan Cheng

Service type: Knock-in mice

2024

FASEB J 2024 Sep;38(17):e70022. doi: 10.1096/fj.202400829R.

Unraveling the role of MiR-181 in skin fibrosis pathogenesis by targeting NUDT21

Tingting W Mills, Minghua Wu, Jerry Alonso, Hydia Puente, Julio Charles, Zheng Chen, Seung-Hee Yoo, Maureen D Mayes, Shervin Assassi

Service type: Knock-in mice

2024

Metallomics. 2024 Sep 5;16(9):mfae036. doi: 10.1093/mtomcs/mfae036.

Decreased spinal cord motor neuron numbers in mice depleted of central nervous system copper

J R Liddell, J B W Hilton, Y J Wang, J L Billings, S Nikseresht, K Kysenius, J P Fuller-Jackson, D J Hare, P J Crouch

Service type: Stock strains

2024

J Med Chem. 2024 Aug 22;67(16):14493-14523. doi: 10.1021/acs.jmedchem.4c01241. Epub 2024 Aug 12.

Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4

Trent D Ashton, Petar P S Calic, Madeline G Dans, Zi Kang Ooi, Qingmiao Zhou, Josephine Palandri, Katie Loi, Kate E Jarman, Deyun Qiu, Adele M Lehane, Bikash Chandra Maity, Nirupam De, Carlo Giannangelo, Christopher A MacRaild, Darren J Creek, Emma Y Mao, Maria R Gancheva, Danny W Wilson, Mrittika Chowdury, Tania F de Koning-Ward, Mufuliat T Famodimu, Michael J Delves, Harry Pollard, Colin J Sutherland, Delphine Baud, Stephen Brand, Paul F Jackson, Alan F Cowman, Brad E Sleebs.

Service type: Stock strains

2024

PNAS Nexus. 2024 Jul 26;3(8):pgae299. doi: 10.1093/pnasnexus/pgae299. eCollection 2024 Aug.

Neuropeptide Y receptor activation preserves inner retinal integrity through PI3K/Akt signaling in a glaucoma mouse model

Viswanthram Palanivel, Vivek Gupta, Nitin Chitranshi, Ole Tietz, Roshana Vander Wall, Reuben Blades, Kanishka Pushpitha Maha Thananthirige, Akanksha Salkar, Chao Shen, Mehdi Mirzaei, Veer Gupta, Stuart L Graham, Devaraj Basavarajappa.

Service type: Stock strains

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