NOD
NOD
| Strain details | |
|---|---|
| Nomenclature | NOD/ShiLtJOzArc |
| Common name | NOD |
| Synonyms | Non-obese Diabetic, NOD/LtJ |
| Strain | Inbred |
| Coat colour | Albino (A/A Tyrc/Tyrc) |
| Species | Mouse |
| JAX stock number | 001976 |
| Location | Area Oz2 |
| Weekly wean target | 20 males, 50 females |
Strain description
- MHC haplotype: H2Kg7
- Complement factor: C5 deficient
- The Jackson Laboratory reports that diabetes occurs in 90-100% of females by 30 weeks of age and 40-60% of males by 30-40 weeks of age.
- Susceptibility to diabetes is polygenic and environment factors such as housing conditions, health status and diet exert a strong effect on penetrance.
- Females produce 4 to 5 litters before becoming diabetic.
- Female breeders are aggressive.
- The incidence of diabetes in males is influenced by environmental factors including pathogens in an inverse relationship i.e. higher incidence of diabetes in germfree animals than conventional animals.
- Mice free from diabetes by 1 year are prone to develop follicle centre cell lymphomas.
- Important Note: This strain is homozygous for Cdh23ahl, the age-related hearing loss 1 mutation, which on this background results in progressive hearing loss that is already severe by three months of age.
- Strain was formerly called NOD/LtJ until 2007 when it was changed to NOD/ShiLtJ
- This strain was transferred from ARC to Ozgene ARC in 2023.
- This strain is used in immunology and inflammation research and is a polygenic model for type 1 diabetes.
Past ARC and transfer reports:
Current Ozgene ARC reports (from 01-Jun-2023)
- This strain is housed in Area Oz2/3/5
- Please see Oz2/3/5 health reports on our Biosecurity page
- These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: JAX General Terms and Conditions.
- JAX mice are the gold standard for animal model research.
- Ozgene ARC terms and Conditions
- Mouse images are representative only. Actual phenotypes may vary based on genotype, sex, age, husbandry, health status, and other factors.
- See www.jax.org for more strain information.
