A2Kb
A2Kb
| Strain details | |
|---|---|
| Nomenclature | C57BL/6J-Tg(HLA-A2/H2-K)6Scr/HsdOzarc |
| Common name | A2Kb |
| Synonyms | A2Kb, HLA A2Kb |
| Strain | Transgenic |
| Coat Colour | Dark grey |
| Species | Mouse |
| Genetic background | C57BL/6J |
| Location | Area Oz2 |
| Weekly wean target | 0 (request specific breeding) |
Strain description
- MHC haplotype: H2Kb
- Complement factor: C5 normal
- A2Kb strain is a transgenic mouse strain that has the A2Kb gene containing the human HLA.
- A2Kb strain is known to exhibit congenital abnormalities such as microphthalmia, corneal opacities, anophthalmia and hydrocephalus.
- This strain demonstrates average breeding performance, with litters lost at approximately 17 days after birth.
- However, it has been observed that providing a high-fat diet to the mice prevents the loss of litters.
- Researchers utilizing the A2Kb strain may consider the influence of the C57BL/6JOzArc background strain when interpreting experimental results and designing further experiments.
- Dr. Linda Sherman, Dept. Immunology, Scripps Research Institute. Animals were imported in 1994 for Dr Jane Allen at UWA from Harlan US by ARC.
- Colony was returned and rederived at ARC in c. 1996.
- This strain is applicable in research related to immunology and transplantation.
- The congenital abnormalities can be useful in studying the developmental processes of the eyes and brain, as well as potential therapeutic interventions for these conditions.
Past ARC and transfer reports:
Current Ozgene ARC reports (from 01-Jun-2023)
- This strain is housed in Area Oz2/3/5
- Please see Oz2/3/5 health reports on our Biosecurity page
- Animals are not allowed to be used for propagation.
- Ozgene ARC terms and Conditions
- Mouse images are representative only. Actual phenotypes may vary based on genotype, sex, age, husbandry, health status, and other factors.
