CBH nude
CBH nude
| Strain details | |
|---|---|
| Nomenclature | CBH-Foxn1rnu/Ozarc |
| Common name | CBH RNU |
| Synonyms | RNU nude, athymic nude |
| Strain | Mutant Inbred |
| Coat colour | Black hooded (a, B, C, h) |
| Species | Rat |
| Location | Area Oz1 |
| Weekly wean target | <10 males, <10 females |
Strain description
- MHC haplotype: RT1c
- Homozygotes have little or no hair and are athymic.
- Heterozygotes have hair and functioning thymus.
- Prone to dust in their eyes due to lack of eyelashes.
- Similar dysgenesis to nude mutation in mice.
- Cell mediated immunity greatly reduced or absent with a marked reduction of T-lymphocyte function.
- Extremely susceptible to infection with Clostridium piliforme.
- Housed in an isolator.
- “Mutation originated in outbred stock at Rowett Research Institute, Aberdeen. CBH strain (Chester Beatty Hooded) originated from Lister hooded colony from Woodruff, Edinburgh. Sent to Institute of Cancer Research UK, 1963.
- Received at ARC from Institute of Cancer Research, Sutton (1984), as SPF animals. Isolator reared until 1990 when they were removed from the isolator and re-derived back on to inbred Wistar received from University of NSW, SPF Facility. Rederived in 1993, 2000 into isolators, 2010 and 2015.”
- CBH rats are transferred from ARC to Ozgene ARC in 2023.
- Tumor biology, immunology, and xenograft research.
Past ARC and transfer reports:
Current Ozgene ARC reports (from 01-Jun-2023)
- This strain is housed in Area Oz1
- Please see Oz1 health reports on our Biosecurity page
- Animals are not allowed to be used for propagation.
- Ozgene ARC terms and Conditions
- Mouse images are representative only. Actual phenotypes may vary based on genotype, sex, age, husbandry, health status, and other factors.
