A/J

Strain details
Nomenclature	A/JOzarc
Common name	A/J
Synonyms	A
Strain	Inbred
Coat colour	Albino (a/a Tyrp1^b/Tyrp1^b Tyr^c/Tyr^c)
Species	Mouse
Genetic background	-
JAX stock number	000646
Location	Area Oz2
Weekly wean target	<10 males, <10 females

Strain description

MHC haplotype: H2K^a
Complement factor: C5 deficient
High social dominance of males in competition for females.
High spontaneous incidence of lung adenomas and mammary tumours in breeding females.
Congenital defects include cleft lip/palate and polydactyly at a prevalence of up to 10%.
Incidence of nephritis and amyloidosis nearly 100% at 15 months.
Low aggression and low responsiveness in general (activity, alcohol, anaesthesia, metabolism).
Presence of hearing loss and blindness.
A/J mice are challenging breeders, exhibiting reduced productivity and high incidence of non-productive matings. They may require some special maintenance. A/J mice tend to be very docile and easy to work with. A 2022 study found vaginal septa in <2% of females.

A/J inbred mice were developed by LC Strong in 1921 from a cross between a Cold Spring Harbor albino and a Bagg albino stock.
The strain was subsequently maintained and bred by Arthur Cloudman after receiving breeders in 1928.

A/J inbred mice are a valuable model for a wide range of research areas, including cancer, immunology, cardiovascular, developmental biology, sensorineural, behaviour, and disease studies.
They are also used in studies on CD antigens, antigen receptors, and histocompatibility markers.

Past ARC and transfer reports:

Current Ozgene ARC reports (from 01-Jun-2023)

These mice are sold subject to The Jackson Laboratory’s Conditions of Use and also the Australian Patent Number (2004268530). Information regarding conditions of use is available at: JAX General Terms and Conditions
JAX mice are the gold standard for animal model research
Ozgene ARC terms and Conditions